College of Health Science

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Browsing College of Health Science by Author "Bekalu Tsegaye"

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    Human papillomavirus vaccination uptake and its associated factors among female adolescent students in Chole Woreda, Arsi Zone, Oromia Regional State, Ethiopia, 2025
    (2025-05-01) Bekalu Tsegaye
    Abstract Background: While HPV is the leading cause of cervical cancer and its vaccine is the only most effective and cost-efficient solution for prevention, uptake has been lagging. The Human Papillomavirus vaccine offers great promise in reducing the cervical cancer burden; however, this low uptake is particularly evident in low-resource settings, such as Ethiopia, where the contextual factors influencing acceptance remain under-explored. Objective: To assess the uptake of Human Papillomavirus vaccination and its associated factors among female adolescent students in Chole Woreda, Arsi Zone, Oromia Regional State, Ethiopia, in 2025. Methods: A mixed-methods cross-sectional study was conducted on female adolescent students in Chole Woreda from September to November 2025. The study used multi-stage proportional sampling across eight schools. Data were collected via Kobo Collect and analyzed in SPSS, with statistical significance set at p<0.05 in multivariable logistic regression. The qualitative findings were analyzed with manual thematic analysis. Result: The HPV vaccine uptake in the study area was found to be 60.6%. Multivariable logistic regression identified five key factors independently associated with this uptake: attitude towards HPV vaccination (AOR = 0.03; 95% CI: 0.01, 0.08; p<0.01), Fathers' educational level (AOR = 0.02; CI: 0.00, 0.09; p<0.01), knowledge towards cervical cancer (AOR = 0.19; 95% CI: 0.06, 0.59; p<0.01), place of birth (AOR = 0.30; 95% CI: 0.10, 0.92; p<0.05), and occupational status of the mother (AOR = 0.14; 95% CI: 0.02, 0.85; p<0.05). These quantitative findings were further corroborated by qualitative results, which revealed that misconceptions and a lack of awareness were significant barriers to vaccine acceptance. Conclusion: HPV vaccine uptake in Chole Woreda is significantly hampered by knowledge deficits, misconceptions, and influential parental socio-demographic factors. Therefore, targeted interventions focusing on parental education and correcting misconceptions are critically recommended to boost vaccination uptake. Key words: Human papillomavirus vaccination, Knowledge, Attitude.